Drug Information

Drug General Information
Drug ID
D02WRO
Former ID
DIB012700
Drug Name
11-beta-HSD1 inhibitors
Synonyms
11beta-hydroxysteroid dehydrogenase-1 inhibitors (metabolic disorder), Sanofi
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Investigative [552167]
Company
Sanofi
Canonical SMILES
c1cccc2c1N(CCN2c1ncc(cn1)c1ccc(cc1)OC)C(=O)N1CCC(C1)c1c<br />n[nH]c1
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [543704]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 552167WO patent application no. 2006134481, INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1.
Ref 543704(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.