Drug Information

Drug General Information
Drug ID
D02VPW
Former ID
DIB018206
Drug Name
[3H](-)CGP 12177
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540763]
Formula
C14H21N3O3
InChI
InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)/t9-/m0/s1
InChIKey
UMQUQWCJKFOUGV-VIFPVBQESA-N
PubChem Compound ID
6603756
PubChem Substance ID
11110881, 11113941, 11646364, 16602026, 43223554, 53476898, 103208714, 103995660, 114636898, 124879486, 134341072, 135651142, 140894023, 198956530, 237414724, 247468488
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [527025]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540763(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 531).
Ref 527025Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):525-32. Epub 2004 Apr 2.

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