Drug Information

Drug General Information
Drug ID
D02UDJ
Former ID
DNC002629
Drug Name
D-Serine
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [467510], [521721]
Formula
C3H7NO3
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKey
MTCFGRXMJLQNBG-UWTATZPHSA-N
CAS Number
CAS 312-84-5
PubChem Compound ID
71077
PubChem Substance ID
4003, 588250, 626975, 829388, 839068, 7887195, 8143525, 8194408, 14747454, 15146420, 17405644, 24278008, 26718244, 26753645, 26753646, 43127470, 46392862, 46508200, 47811035, 47885661, 48110736, 49748509, 49846980, 50045910, 50096464, 50096469, 50106988, 50106989, 53778194, 56312452, 56313140, 56437651, 57318000, 80530258, 85756772, 87350321, 87575662, 87636300, 90341480, 92298581, 92303181, 92717308, 99213597, 99224311, 103060962, 103204181, 103822437, 104038215, 104349603, 117518385
Target and Pathway
Target(s) NMDA receptor subunit NR1 Target Info Inhibitor [551378]
Glycine receptor alpha-1 chain Target Info Inhibitor [551378]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-975298:Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 467510(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4171).
Ref 521721ClinicalTrials.gov (NCT00215904) D-serine Adjuvant Treatment for Parkinson's Disease. U.S. National Institutes of Health.
Ref 551378Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.

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