Drug Information

Drug General Information
Drug ID
D02SDM
Former ID
DIB020252
Drug Name
LU32-176B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467997]
Formula
C23H24F2N2O2
InChI
InChI=1S/C23H24F2N2O2/c24-17-10-6-15(7-11-17)19(16-8-12-18(25)13-9-16)3-2-14-26-20-4-1-5-21-22(20)23(28)27-29-21/h6-13,19-20,26H,1-5,14H2,(H,27,28)
InChIKey
QOSIKKDOOCQXMT-UHFFFAOYSA-N
PubChem Compound ID
11749893
PubChem Substance ID
16857523, 42791935, 77213489, 178101466, 231521351
Target and Pathway
Target(s) BGT1 Target Info Inhibitor [527297]
Sodium- and chloride-dependent GABA transporter 1 Target Info Inhibitor [527297]
KEGG Pathway GABAergic synapse
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
References
Ref 467997(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4756).
Ref 527297First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. Epub 2004 Nov 18.

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