Drug Information

Drug General Information
Drug ID
D02OAI
Former ID
DIB018782
Drug Name
AGN193836
Synonyms
AGN-193836; AGN 193836
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539715]
Formula
C22H22BrF2NO4
InChI
InChI=1S/C22H22BrF2NO4/c1-21(2)5-6-22(3,4)16-11(21)9-14(18(27)17(16)23)26-19(28)10-7-12(24)15(20(29)30)13(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)
InChIKey
FADQHUSDAKOWFT-UHFFFAOYSA-N
PubChem Compound ID
23001780
PubChem Substance ID
127816690, 135649904, 232804859
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Agonist [526437]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539715(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2649).
Ref 526437Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.Synthesis and biological activity of retinoic acid receptor-alpha specific amides.

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