Drug Information

Drug General Information
Drug ID
D02KBO
Former ID
DIB007674
Drug Name
Ciprokiren
Synonyms
Ro-44-9375
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545961]
Company
F Hoffmann-La Roche Ltd
Formula
C37H55N5O8S
Canonical SMILES
S(=O)(=O)(C(C(=O)N1CCOCC1)(C)C)C[C@H](C(=O)N[C@H](C(=O)<br />N[C@H]([C@H]([C@H](C1CC1)O)O)CC1CCCCC1)Cc1nc[nH]c1)Cc1c<br />cccc1
CAS Number
CAS 143631-62-3
PubChem Compound ID
5312136
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [533865]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 545961Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005529)
Ref 533865Ciprokiren (Ro 44-9375). A renin inhibitor with increasing effects on chronic treatment. Hypertension. 1994 Aug;24(2):163-9.

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