Drug Information

Drug General Information
Drug ID
D02HNE
Former ID
DNC008260
Drug Name
5-(2-(pyrrolidin-1-yl)ethyl)isothiazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529212]
Formula
C9H14N2S
Canonical SMILES
C1CCN(C1)CCC2=CC=NS2
InChI
1S/C9H14N2S/c1-2-7-11(6-1)8-4-9-3-5-10-12-9/h3,5H,1-2,4,6-8H2
InChIKey
GRXWPIZSBSTAQX-UHFFFAOYSA-N
PubChem Compound ID
44456451
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [529212]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529212Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. Epub 2007 Oct 24.In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Ref 529212Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. Epub 2007 Oct 24.In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.