Drug Information

Drug General Information
Drug ID
D02GEC
Former ID
DAP000387
Drug Name
Omalizumab
Synonyms
Xolair; Omalizumab (genetical recombination); Xolair (TN); Omalizumab (USAN/INN); Omalizumab (genetical recombination) (JAN)
Drug Type
Monoclonal antibody
Indication Asthma; Chronic idiopathic urticaria [ICD10:J45, L50] Approved [536361], [541948], [889349], [889383]
Chronic idiopathic urticaria [ICD9: 708; ICD10:L50] Phase 2 [536361], [541948]
Therapeutic Class
Antiasthmatic Agents
Company
National University Hospital, Singapore|National University, Singapore
Formula
C6450H9916N1714O2023S38
CAS Number
CAS 242138-07-4
PubChem Substance ID
47206967
SuperDrug ATC ID
R03DX05
Target and Pathway
Target(s) High affinity immunoglobulin epsilon receptor Target Info Modulator [889443]
KEGG Pathway Sphingolipid signaling pathway
Fc epsilon RI signaling pathway
Asthma
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
WikiPathways IL1 and megakaryotyces in obesity
Fc epsilon receptor (FCERI) signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541948(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6890).
Ref 889349ClinicalTrials.gov (NCT00546143) Safety and Tolerability of Omalizumab in Patients With Mild to Moderate Asthma
Ref 889383ClinicalTrials.gov (NCT01701583) Effect of Omalizumab (Xolair) on Basophils in Patients With Chronic Idiopathic Urticaria
Ref 889443The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. doi: 10.1038/nrd3792.

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