Drug Information

Drug General Information
Drug ID
D02FEV
Former ID
DIB014340
Drug Name
S-8921
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 2 [534690]
Company
Shionogi & Co Ltd
Formula
C30H36O9
Canonical SMILES
c1(c(c(c2c(c1O)cc(c(c2OC)OC)OC)c1cc(c(cc1)OC)OC)C(=O)OC<br />)C(=O)CC(CC)CC
CAS Number
CAS 151165-96-7
PubChem Compound ID
153965
Target and Pathway
Target(s) Ileal bile acid transfer Target Info Inhibitor [534690]
KEGG Pathway Bile secretion
Reactome Recycling of bile acids and salts
WikiPathways Bile acid and bile salt metabolism
References
Ref 534690Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.
Ref 534690Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.

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