Drug Information

Drug General Information
Drug ID
D02ETA
Former ID
DIB018844
Drug Name
AMN082
Synonyms
AMN-082; AMN 082
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538918]
Formula
C28H28N2
InChI
InChI=1S/C28H28N2/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20,27-30H,21-22H2
InChIKey
DTZDSNQYNPNCPK-UHFFFAOYSA-N
PubChem Compound ID
1894361
PubChem Substance ID
3346377, 5220278, 8047643, 9162664, 25667234, 26753295, 29215138, 32754368, 49647468, 78522678, 88565595, 90341217, 108217072, 110758246, 125172698, 127786746, 135649940, 141012483, 164074177, 169080761, 179075859, 233635732, 242196826, 252638182
Target and Pathway
Target(s) Metabotropic glutamate receptor 7 Target Info Modulator (allosteric modulator) [527924]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538918(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1441).
Ref 527924A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. Epub 2005 Dec 9.

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