Drug Information

Drug General Information
Drug ID
D02EMH
Former ID
DIB018803
Drug Name
all-trans-4-oxo-retinoic acid
Synonyms
4-oxoretinoic acid; Ro 12-4824
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539786]
Formula
C20H26O3
InChI
InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+
InChIKey
GGCUJPCCTQNTJF-FRCNGJHJSA-N
PubChem Compound ID
6437063
PubChem Substance ID
11967685, 14825854, 24702089, 43030186, 50044411, 51091001, 53789010, 57367826, 75953387, 103321793, 114552551, 126525656, 135060320, 135649918, 137136067, 164227882, 164761474, 164761476, 164761478, 179654657, 223445642, 226524258, 252165401, 252341043
Target and Pathway
Target(s) RAR-related orphan receptor-beta Target Info Antagonist [526714]
Alpha-2C adrenergic receptor Target Info Antagonist [527472]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 539786(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2741).
Ref 526714All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 2003 Oct;10(10):820-5. Epub 2003 Sep 7.
Ref 527472Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. J Med Chem. 2005 Mar 24;48(6):1709-12.

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