Drug Information

Drug General Information
Drug ID
D02DOP
Former ID
DNC004989
Drug Name
3-(1-Pyridin-2-yl-1H-pyrazol-3-yl)-benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527190]
Formula
C15H10N4
Canonical SMILES
C1=CC=NC(=C1)N2C=CC(=N2)C3=CC=CC(=C3)C#N
InChI
1S/C15H10N4/c16-11-12-4-3-5-13(10-12)14-7-9-19(18-14)15-6-1-2-8-17-15/h1-10H
InChIKey
LQROCYQCXGUXNA-UHFFFAOYSA-N
PubChem Compound ID
10236192
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [527190]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527190J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
Ref 527190J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

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