Drug Information

Drug General Information
Drug ID
D02BOW
Former ID
DIB020314
Drug Name
McN-A-343
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532883]
Formula
C14H18Cl2N2O2
InChI
InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
InChIKey
CXFZFEJJLNLOTA-UHFFFAOYSA-N
PubChem Compound ID
5926
PubChem Substance ID
7979865, 8153674, 14874555, 17404840, 29224951, 46500418, 49868158, 50106034, 53777383, 57323054, 79034981, 92303548, 99029911, 103136848, 103273027, 104310635, 117371041, 121360960, 124801325, 125541004, 134222881, 134972116, 135650571, 135697844, 137231119, 162226357, 163564231, 175612335, 178126905, 179293821, 198959015, 229036075, 241097765, 241182383, 241375396
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Agonist [533662]
Muscarinic receptor Target Info Agonist [533018]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 532883International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacol Rev. 2014 Oct;66(4):918-47.
Ref 533018Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. J Pharmacol Exp Ther. 1989 Feb;248(2):661-70.
Ref 533662Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists. Br J Pharmacol. 1995 Mar;114(6):1241-9.

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