Drug Information

Drug General Information
Drug ID
D02AVN
Former ID
DNC011790
Drug Name
(3-Chloro-phenyl)-piperazin-1-yl-methanone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533476]
Formula
C11H13ClN2O
Canonical SMILES
C1CN(CCN1)C(=O)C2=CC(=CC=C2)Cl
InChI
1S/C11H13ClN2O/c12-10-3-1-2-9(8-10)11(15)14-6-4-13-5-7-14/h1-3,8,13H,4-7H2
InChIKey
FBTDRVSCKFZIQH-UHFFFAOYSA-N
PubChem Compound ID
1074765
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [533476]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [533476]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.

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