Drug Information

Drug General Information
Drug ID
D01ZDR
Former ID
DIB011410
Drug Name
FR-208419
Synonyms
IDDB16886
Drug Type
Small molecular drug
Indication Dyspepsia [ICD9: 536.8; ICD10:K30] Terminated [546824]
Company
Fujisawa Pharmaceutical Co Ltd
Formula
C28H34N4O3
Canonical SMILES
N1(c2c(C(=N[C@H](NC(=O)Nc3cc(ccc3)C)C1)CC)cccc2C)CC(=O)<br />C1CCCCC1
PubChem Compound ID
6918392
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Modulator [525711]
Cholecystokinin receptor type A Target Info Modulator [525711]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 546824Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010485)
Ref 525711Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15.

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