Drug Information

Drug General Information
Drug ID
D01YDF
Former ID
DIB015753
Drug Name
Pibutidine
Synonyms
Alex; Pibutidine hydrochloride; IT-066
Drug Type
Small molecular drug
Indication Ulcerative colitis [ICD9: 556; ICD10:K51] Discontinued in Phase 3 [544697]
Company
Ikeda Mohando Co Ltd
Formula
C19H24N4O3
Canonical SMILES
C1(=C(C(=O)C1=O)N)NC/C=C\COc1nccc(CN2CCCCC2)c1.Cl
PubChem Compound ID
5282450
Target and Pathway
Target(s) Histamine H2 receptor Target Info Modulator [533592]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544697Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641)
Ref 533592Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82.

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