Drug Information

Drug General Information
Drug ID
D01XHG
Former ID
DNC003764
Drug Name
DENBUFYLLINE
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 3 [525628]
Formula
C16H24N4O3
Canonical SMILES
CCCCN1C2=C(C(=O)N(C1=O)CCCC)N(C=N2)CC(=O)C
InChI
1S/C16H24N4O3/c1-4-6-8-19-14-13(18(11-17-14)10-12(3)21)15(22)20(16(19)23)9-7-5-2/h11H,4-10H2,1-3H3
InChIKey
HJPRDDKCXVCFOH-UHFFFAOYSA-N
PubChem Compound ID
2984
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [526336]
Type IV phosphodiesterase Target Info Inhibitor [526336]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [526336]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 525628Denbufylline in dementia: a double-blind controlled study. Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):505-10.
Ref 526336J Med Chem. 2002 May 23;45(11):2342-5.Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers.

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