Drug Information

Drug General Information
Drug ID
D01WYV
Former ID
DIB013399
Drug Name
Angiostatin/paclitaxel/carboplatin
Indication Lung cancer [ICD9: 162; ICD10:C33-C34] Investigative [527516], [530307]
Company
EntreMed
Target and Pathway
Target(s) Tubulin beta-1 chain Target Info Modulator [527516], [530307]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway TSH Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Translocation of GLUT4 to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Recruitment of NuMA to mitotic centrosomes
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Hedgehog 'off' state
Assembly of the primary cilium
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
Mitotic Prometaphase
Kinesins
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Protein folding
References
Ref 527516Pharm Res. 2005 Mar;22(3):347-55.Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850).
Ref 530307Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
Ref 527516Pharm Res. 2005 Mar;22(3):347-55.Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850).
Ref 530307Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.

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