Drug Information

Drug General Information
Drug ID
D01UZT
Former ID
DNC012974
Drug Name
4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528080]
Formula
C14H10ClN3
Canonical SMILES
C1=CC=NC(=C1)N2C=C(C=N2)C3=CC=C(C=C3)Cl
InChI
1S/C14H10ClN3/c15-13-6-4-11(5-7-13)12-9-17-18(10-12)14-3-1-2-8-16-14/h1-10H
InChIKey
NJMIDEUMQUSYDE-UHFFFAOYSA-N
PubChem Compound ID
44408653
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528080]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.