Drug Information

Drug General Information
Drug ID
D01SNS
Former ID
DIB020038
Drug Name
IIK7
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538828]
Formula
C22H24N2O2
InChI
InChI=1S/C22H24N2O2/c1-3-6-21(25)23-12-11-18-19-13-16(26-2)9-10-20(19)24-14-15-7-4-5-8-17(15)22(18)24/h4-5,7-10,13H,3,6,11-12,14H2,1-2H3,(H,23,25)
InChIKey
RQYIUGOJQFWLAZ-UHFFFAOYSA-N
PubChem Compound ID
4172142
PubChem Substance ID
6118078, 7979589, 8373589, 11111322, 14925275, 17405262, 24278492, 35459261, 47795042, 50106514, 50106515, 53777807, 57356804, 78932784, 85209108, 85231091, 92304322, 103169764, 103985422, 112738136, 124749928, 124880425, 129169065, 135650375, 162250176, 163135169, 179235824
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [525729]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538828(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1350).
Ref 525729Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.J Med Chem. 2000 Mar 23;43(6):1050-61.

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