Drug Information

Drug General Information
Drug ID
D01QAR
Former ID
DIB010461
Drug Name
LY-221068
Drug Type
Small molecular drug
Indication Arthritis [ICD9: 710-719; ICD10:M00-M25] Terminated [545172]
Company
Eli Lilly & Co
Formula
C20H30N2O2S
Canonical SMILES
N1(C(=O)/C(=C/c2cc(c(c(C(C)(C)C)c2)O)C(C)(C)C)/SC1)N(C)<br />C
CAS Number
CAS 132392-39-3
PubChem Compound ID
6439333
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [529094]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545172Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002348)
Ref 529094Anti-inflammatory effects of LY221068 and LY269415. Agents Actions. 1991 Sep;34(1-2):100-2.

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