Drug Information

Drug General Information
Drug ID
D01MYN
Former ID
DIB011357
Drug Name
LY-2523199
Synonyms
11-beta hydroxysteroid dehydrogenase type 1 inhibitor (diabetes), Eli Lilly; 11-beta-HSD-1 inhibitor (type 2 diabetes), Eli Lilly
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 2 [549275]
Company
Eli Lilly & Co
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [549810]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 549275Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034519)
Ref 549810Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease. before print June 15, 2014.

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