Drug Information

Drug General Information
Drug ID
D01LXG
Former ID
DIB006505
Drug Name
KC-11425
Indication Asthma [ICD10:J45] Terminated [545947]
Company
Solvay Pharmaceuticals Inc
Canonical SMILES
n12c(c(c3c1c(cc(c3)CC(C)C)CCC2)CCN1CCN(c2nccc(c2)C)CC1)<br />C.Cl.Cl
CAS Number
CAS 148468-63-7
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [551926]
Arachidonate 5-lipoxygenase Target Info Antagonist [551926]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infectionhsa00590:Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling PathwayNetPath_16:IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signalingWP2877:Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545947Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005461)
Ref 551926WO patent application no. 2002,01223,5, 1,4-dihydropyridines as bradykinin antagonists.

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