Drug Information

Drug General Information
Drug ID
D01LRM
Former ID
DIB001976
Drug Name
SBC-014
Synonyms
AVI-014; Glycosylated recombinant G-CSF (neutropenia), AviGenics; Glycosylated recombinant G-CSF (neutropenia), Synageva
Indication Neutropenia [ICD9: 288; ICD10:D70] Phase 2 [522057]
Company
Synageva BioPharma Corp
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Modulator [544066]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 522057ClinicalTrials.gov (NCT00497809) Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia. U.S. National Institutes of Health.
Ref 544066A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.

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