Drug Information

Drug General Information
Drug ID
D01JFF
Former ID
DIB021184
Drug Name
VU0361737
Synonyms
VU-0361737; VU 0361737; compound 9b [PMID: 19469556]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530167]
Formula
C13H11ClN2O2
InChI
InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
InChIKey
ARYUXFNGXHNNDM-UHFFFAOYSA-N
PubChem Compound ID
44191096
PubChem Substance ID
85186890, 85240643, 89949909, 103683884, 104135272, 135698913, 162009821, 162012054, 163123660, 172919857, 178100783, 204356818, 210024050, 223382486, 225373249, 240855801, 241376595, 242060093, 251910369, 252157472, 252160501, 252216596, 252446763, 252473858
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator (allosteric modulator) [530167]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 530167Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8.
Ref 530167Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8.

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