Drug Information

Drug General Information
Drug ID
D01IGU
Former ID
DIB018863
Drug Name
APA
Synonyms
1-aminooxy-3-aminopropane
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468201]
Formula
C3H10N2O
InChI
InChI=1S/C3H10N2O/c4-2-1-3-6-5/h1-5H2
InChIKey
VSZFWDPIWSPZON-UHFFFAOYSA-N
PubChem Compound ID
65020
PubChem Substance ID
8189449, 15041206, 22425646, 24902366, 24902368, 43121865, 50338680, 57315243, 57551989, 103196958, 103919167, 104332654, 125670366, 129522635, 132631105, 134350425, 135022886, 137010620, 141796018, 142919893, 162755640, 178101831, 179113908, 241169678
Target and Pathway
Target(s) Ornithine decarboxylase Target Info Inhibitor [527450]
BioCyc Pathway Putrescine biosynthesis I
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
References
Ref 468201(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5139).
Ref 5274502-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.

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