Drug Information

Drug General Information
Drug ID
D01HST
Former ID
DIB018833
Drug Name
amg-1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531599]
Formula
C20H16N4O3S2
InChI
InChI=1S/C20H16N4O3S2/c1-12-2-4-13(5-3-12)15-9-28-19-22-23-20(24(15)19)29-10-18(25)21-14-6-7-16-17(8-14)27-11-26-16/h2-9H,10-11H2,1H3,(H,21,25)
InChIKey
XYXNYQAJSYUYNZ-UHFFFAOYSA-N
PubChem Compound ID
1085108
PubChem Substance ID
1360639, 3591882, 4095427, 5521584, 8761668, 42130216, 51338026, 87713846, 105204746, 110214589, 118407951, 130915592, 143964303, 164058544, 168524980, 179714171, 249565907
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [531599]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 531599Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814(12):1947-54.
Ref 531599Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814(12):1947-54.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.