Drug Information

Drug General Information
Drug ID
D01FOK
Former ID
DNC011332
Drug Name
7-ethoxy-8-propionyl-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531259]
Formula
C14H14O4
Canonical SMILES
CCC(=O)C1=C(C=CC2=C1OC(=O)C=C2)OCC
InChI
1S/C14H14O4/c1-3-10(15)13-11(17-4-2)7-5-9-6-8-12(16)18-14(9)13/h5-8H,3-4H2,1-2H3
InChIKey
LJTVZULEIDSNAK-UHFFFAOYSA-N
PubChem Compound ID
52949288
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info Inhibitor [531259]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.