Drug Information

Drug General Information
Drug ID
D01ERN
Former ID
DIB006555
Drug Name
MGluR5 antagonists (anxiety), Novartis
Synonyms
MGluR5 antagonists (anxiety); MGluR5 antagonists (anxiety), Novartis
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Investigative [543750]
Company
Novartis AG
Canonical SMILES
C(=O)(N1C(CCCC1)CC)c1cnc(c(c1)Cl)Nc1cnc(cc1)C
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Antagonist [543750]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 543750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).
Ref 543750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).

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