Drug Information

Drug General Information
Drug ID
D01CQU
Former ID
DIB020425
Drug Name
MRS1706
Synonyms
MRS-1706; MRS 1706
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540250]
Formula
C27H29N5O5
InChI
InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
InChIKey
ZKUCFFYOQOJLGT-UHFFFAOYSA-N
PubChem Compound ID
5139184
PubChem Substance ID
7623411, 7978521, 8572857, 11114142, 14811045, 38880022, 57357397, 74745224, 103180879, 103985565, 113742187, 135698557, 137015693, 162222772, 178100328, 208265227, 227456495, 241182547, 241375516, 248541882, 249617346
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [525731]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540250(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3287).
Ref 525731Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72.

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