Drug Information

Drug General Information
Drug ID
D01BVR
Former ID
DNC006216
Drug Name
5-(4-piperidyl)-4-propylisothiazol-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528034]
Formula
C11H18N2OS
Canonical SMILES
CCCC1=C(SNC1=O)C2CCNCC2
InChI
1S/C11H18N2OS/c1-2-3-9-10(15-13-11(9)14)8-4-6-12-7-5-8/h8,12H,2-7H2,1H3,(H,13,14)
InChIKey
INIXNNKFVDXPBJ-UHFFFAOYSA-N
PubChem Compound ID
11515063
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528034]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

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