Drug Information

Drug General Information
Drug ID
D00ZGA
Former ID
DCL000741
Drug Name
Casopitant
Synonyms
Rezonic; Zunrisa; GW 679769; GW679769
Drug Type
Small molecular drug
Indication Chemotherapy-induced nausea [ICD9: 787, 787.0; ICD10:R11] Withdrawn from market [536580], [541092]
Company
GlaxoSmithKline
Formula
C30H35F7N4O2
InChI
InChI=1S/C30H35F7N4O2/c1-18-13-24(31)5-6-26(18)27-17-25(40-11-9-39(10-12-40)20(3)42)7-8-41(27)28(43)38(4)19(2)21-14-22(29(32,33)34)16-23(15-21)30(35,36)37/h5-6,13-16,19,25,27H,7-12,17H2,1-4H3/t19-,25+,27-/m1/s1
InChIKey
XGGTZCKQRWXCHW-WMTVXVAQSA-N
CAS Number
CAS 414910-30-8
PubChem Compound ID
9917021
PubChem Substance ID
14887512, 16614672, 24195820, 45988670, 80440491, 124965644, 125086677, 135252706, 135263916, 137248711, 137933165, 140844714, 164837854, 178102383, 198941397, 223847907, 226750227, 243015175
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [536580]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 541092(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5758).
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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