Drug Information

Drug General Information
Drug ID
D00YLW
Former ID
DAP000368
Drug Name
Dolasetron
Synonyms
Dolasetronum; Dolasteron; Anzemet (TN); Dolasetron (INN); Dolasetron [INN:BAN]; Dolasetronum [INN-Latin]; 3-oxooctahydro-2h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate
Drug Type
Small molecular drug
Indication Nausea; Vomiting [ICD9: 787, 787.0; ICD10:R11] Approved [536361]
Therapeutic Class
Antiemetics
Company
Aventis Pharmaceuticals Inc.
Formula
C19H20N2O3
Canonical SMILES
C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54
InChI
1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13+,14?
InChIKey
UKTAZPQNNNJVKR-AKJUYKBHSA-N
CAS Number
CAS 115956-12-2
PubChem Compound ID
3033818
PubChem Substance ID
14752879, 14951072, 26688188, 32961384, 36077657, 50281384, 93166445, 111635088, 135027020, 136064078, 137005045, 176243013, 179116657, 179466495, 184633448, 194179162, 215784161, 223571622, 224121779, 225145402, 226426925, 226426926, 252077520, 252316461, 252478485
SuperDrug ATC ID
A04AA04
SuperDrug CAS ID
cas=115956122
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Antagonist [537011]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537011Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial.Lancet Oncol. 2009 Feb;10(2):115-24. Epub 2009 Jan 8.

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