Drug Information

Drug General Information
Drug ID
D00XZP
Former ID
DIB013950
Drug Name
UR-7198
Synonyms
UR-7198; UR-7247; UR-7280; Angiotensin II AT-1 antagonists, Uriach; UR-7280 analogs, Uriach
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [546845]
Company
Grupo Uriach
Canonical SMILES
c1(c(n(nc1C(C)(C)C)CCC)Cc1ccc(c2c(c3nnn[nH]3)cccc2)cc1)<br />C(=O)O
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Antagonist [525714]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 546845Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010597)
Ref 525714Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6. J Cardiovasc Pharmacol. 2000 Mar;35(3):383-9.

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