TTD | Drug: D00XEN

Drug General Information
Drug ID	D00XEN
Former ID	DIB020531
Drug Name	NGB 2904
Synonyms	NGB-2904
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541779]
Formula	C28H29Cl2N3O
InChI	InChI=1S/C28H29Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,3-4,12-18H2,(H,31,34)
InChIKey	YJPWVCIGSHWNON-UHFFFAOYSA-N
PubChem Compound ID	9891901
PubChem Substance ID	14859647, 24177272, 45638836, 50112943, 57373697, 80860019, 85222833, 85787671, 103252237, 103965649, 129805201, 178103286, 233339646
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Antagonist	[528948]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Dopaminergic synapse
Reactome	Dopamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 541779	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6674).
Ref 528948	Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. CNS Drug Rev. 2007 Summer;13(2):240-59.

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Drug Information