Drug Information

Drug General Information
Drug ID
D00VYD
Former ID
DIB020861
Drug Name
RS-136270
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542752]
Formula
C12H10ClNO2
InChI
InChI=1S/C12H10ClNO2/c13-10-4-1-3-9(7-10)8-14-6-2-5-11(14)12(15)16/h1-7H,8H2,(H,15,16)
InChIKey
VPTUTBZAHHDMAA-UHFFFAOYSA-N
PubChem Compound ID
5071702
PubChem Substance ID
15267671, 24322078, 79496308, 113697180, 121149530, 135650940, 147960268, 237960117
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [525750]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542752(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 780).
Ref 525750J Biol Chem. 2000 Aug 18;275(33):25562-71.Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helicalbundle.

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