Drug Information

Drug General Information
Drug ID
D00SPK
Former ID
DIB004276
Drug Name
E-4021
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Discontinued in Phase 2 [545643]
Company
Eisai Co Ltd
Formula
C22H20ClN4NaO4
Canonical SMILES
c12c(nc(nc1ccc(c2)Cl)N1CCC(CC1)C(=O)[O-])NCc1cc2c(cc1)O<br />CO2.[Na+]
CAS Number
CAS 150452-18-9
PubChem Compound ID
23665864
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [525427]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 545643Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004019)
Ref 525427Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme. Mol Pharmacol. 1999 Mar;55(3):508-14.

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