Drug Information

Drug General Information
Drug ID
D00NLD
Former ID
DNC003697
Drug Name
L-741604
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546098]
Formula
C14H17N5
Canonical SMILES
CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
InChI
1S/C14H17N5/c1-18(2)6-5-11-8-15-14-4-3-12(7-13(11)14)19-9-16-17-10-19/h3-4,7-10,15H,5-6H2,1-2H3
InChIKey
IGNXHSPBUUSUHB-UHFFFAOYSA-N
PubChem Compound ID
9881526
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [525431]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546098Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006344)
Ref 525431J Med Chem. 1999 Feb 25;42(4):691-705.3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.

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