Drug Information

Drug General Information
Drug ID
D00MQS
Former ID
DCL000919
Drug Name
PD-165167
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Pfizer
Formula
C18H18N2O2
Canonical SMILES
C1=CC=C(C=C1)NCCNCC2=CC3=C(C=C2)C=CC(=O)O3
InChI
1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
InChIKey
RNNKCHJUBXFBQB-UHFFFAOYSA-N
PubChem Compound ID
9926143
PubChem Substance ID
14898134, 24202540, 57373803, 77522997, 85224205, 103352466, 103980921, 129154909, 134339367, 233702527
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Antagonist [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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