Drug Information

Drug General Information
Drug ID
D00MGT
Former ID
DIB020985
Drug Name
SRA880
Synonyms
NVP-SRA880; obelin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539301]
Formula
C26H32N4O4
InChI
InChI=1S/C26H32N4O4/c1-27-17-20(14-19-15-23-18(16-24(19)27)4-3-5-25(23)34-2)26(31)29-12-10-28(11-13-29)21-6-8-22(9-7-21)30(32)33/h3-9,19-20,24H,10-17H2,1-2H3/t19-,20-,24-/m1/s1
InChIKey
INULNSAIIZKOQE-YOSAUDMPSA-N
PubChem Compound ID
5311377
PubChem Substance ID
14760590, 39341058, 46528111, 79091136, 103550927, 114155941, 135651084, 164152172
Target and Pathway
Target(s) Somatostatin receptor 1 Target Info Antagonist [527071]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539301(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2030).
Ref 527071SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. Neurosci Lett. 2004 May 6;361(1-3):132-5.

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