Drug Information

Drug General Information
Drug ID
D00KVE
Former ID
DIB000567
Drug Name
Cutamesine
Synonyms
AGY-94806; Msc-1; SA-4502; SA-4503; Sigma opioid receptor agonist, Santen
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Preclinical [546327]
Company
Santen Pharmaceutical Co Ltd
Formula
C23H32N2O2
Canonical SMILES
N1(CCc2cc(c(cc2)OC)OC)CCN(CC1)CCCc1ccccc1
PubChem Compound ID
9907323
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Agonist [526642], [532713], [534601]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 546327Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007486)
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 534601Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons. Eur J Pharmacol. 1998 Jan 19;342(1):105-11.

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