Drug Information

Drug General Information
Drug ID
D00KQT
Former ID
DIB011092
Drug Name
FR-129169
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Terminated [545283]
Company
Fujisawa Pharmaceutical Co Ltd
Canonical SMILES
C(=O)(NC(Cc1ccccc1)c1ccccc1)Cc1c(OCCCCCCCC)cccc1
CAS Number
CAS 143895-84-5
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [534219]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 545283Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002683)
Ref 534219Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat. Jpn J Pharmacol. 1996 Jan;70(1):35-41.

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