Drug Information

Drug General Information
Drug ID
D00IXN
Former ID
DIB008861
Drug Name
GS-6637
Indication Substance dependence [ICD10:F10-F19] Phase 1 [549559]
Target and Pathway
Target(s) Aldehyde dehydrogenase, mitochondrial Target Info Inhibitor [531635], [550813]
KEGG Pathway Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Fatty acid degradation
Valine, leucine and isoleucine degradation
Lysine degradation
Arginine and proline metabolism
Histidine metabolism
Tryptophan metabolism
beta-Alanine metabolism
Glycerolipid metabolism
Pyruvate metabolism
Metabolic pathways
Biosynthesis of antibiotics
PathWhiz Pathway Beta-Alanine Metabolism
Ethanol Degradation
Histidine Metabolism
Valine, Leucine and Isoleucine Degradation
Pyruvate Metabolism
Oxidation of Branched Chain Fatty Acids
Glycine and Serine Metabolism
Tryptophan Metabolism
WikiPathways Tryptophan metabolism
Fatty Acid Omega Oxidation
Phase 1 - Functionalization of compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 549559Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040688)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 550813Clinical pipeline report, company report or official report of Gilead.

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