Drug Information

Drug General Information
Drug ID
D00IWL
Former ID
DIB009029
Drug Name
PolyHeme
Synonyms
Oxygen-carrying blood substitute, Northfield Laboratories
Indication Blood forming organ disorders [ICD10:D75.9] Phase 3 [521584]
Company
Northfield Laboratories
Target and Pathway
Target(s) Hemoglobin Target Info Modulator [544047]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 521584ClinicalTrials.gov (NCT00076648) Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting. U.S. National Institutes of Health.
Ref 544047Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.

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