Drug Information

Drug General Information
Drug ID
D00HWF
Former ID
DNC002359
Drug Name
Proxyfan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538770]
Formula
C13H16N2O
InChI
InChI=1S/C13H16N2O/c1-2-5-12(6-3-1)10-16-8-4-7-13-9-14-11-15-13/h1-3,5-6,9,11H,4,7-8,10H2,(H,14,15)
InChIKey
WNWALBVQAAIULR-UHFFFAOYSA-N
PubChem Compound ID
6421522
PubChem Substance ID
15018514, 29215555, 43015674, 49846729, 50425566, 56224795, 85083153, 85789097, 103184079, 103995299, 114519688, 135279529, 135650860, 136065000, 137132887, 140691979, 144233393, 230033402, 240855570, 249954442
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [536039]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538770(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1255).
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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