Drug Information

Drug General Information
Drug ID
D00HFD
Former ID
DIB005674
Drug Name
E-6080
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [545041]
Company
Eisai Co Ltd
Formula
C17H20ClN3O3S2
Canonical SMILES
c12c(c(c(c(c2C)C)O)C)sc(n1)NCc1ccc(S(=O)(=O)N)cc1.Cl
CAS Number
CAS 120164-49-0
PubChem Compound ID
129064
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [526797]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545041Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001952)
Ref 526797Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. Int Arch Allergy Immunol. 1992;97(4):267-73.

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