Drug Information

Drug General Information
Drug ID
D00FGA
Former ID
DNC004972
Drug Name
Pyrrolidine-1-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527556]
Formula
C5H8N2
Canonical SMILES
C1CCN(C1)C#N
InChI
1S/C5H8N2/c6-5-7-3-1-2-4-7/h1-4H2
InChIKey
QJRYYOWARFCJQZ-UHFFFAOYSA-N
PubChem Compound ID
73737
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [527556]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 527556Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.Acyclic cyanamide-based inhibitors of cathepsin K.
Ref 527556Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.Acyclic cyanamide-based inhibitors of cathepsin K.

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