Drug Information

Drug General Information
Drug ID
D00EPD
Former ID
DNC003671
Drug Name
6-(2-Chloro-benzenesulfonyl)-2H-pyridazin-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527771]
Formula
C10H7ClN2O3S
Canonical SMILES
C1=CC=C(C(=C1)S(=O)(=O)C2=NNC(=O)C=C2)Cl
InChI
1S/C10H7ClN2O3S/c11-7-3-1-2-4-8(7)17(15,16)10-6-5-9(14)12-13-10/h1-6H,(H,12,14)
InChIKey
FTLDTGWMVVXYAM-UHFFFAOYSA-N
PubChem Compound ID
9921581
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [527771]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

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