Drug Information

Drug General Information
Drug ID
D00ECO
Former ID
DNC001327
Drug Name
SIB-1553A
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 2 [546683]
Formula
C13H20ClNOS
Canonical SMILES
CN1CCCC1CCSC2=CC=C(C=C2)O.Cl
InChI
1S/C13H19NOS.ClH/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13;/h4-7,11,15H,2-3,8-10H2,1H3;1H
InChIKey
RJSVKPQKXSMZMT-UHFFFAOYSA-N
CAS Number
CAS 205887-54-3
PubChem Compound ID
9881989
PubChem Substance ID
14848493, 24169449, 45628941, 50005957, 79322603, 87692385, 232066476, 241377169, 249691288, 252158339
Target and Pathway
Target(s) Nicotinic acetylcholine receptor Target Info Agonist [538102]
Neuronal acetylcholine receptor protein, beta-4 chain Target Info Agonist [535261]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Chromaffin Cells
References
Ref 546683Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009631)
Ref 535261SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effectson working and reference memory performances in aged rodents and nonhuman primates. J Pharmacol Exp Ther. 2001 Oct;299(1):297-306.
Ref 538102The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci. 1998;62(17-18):1601-6.

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