Drug Information

Drug General Information
Drug ID
D00EBH
Former ID
DIB009413
Drug Name
ICI-170809
Synonyms
ZM-170809
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [544978]
Company
Zeneca Group plc
Formula
C21H24N2S
Canonical SMILES
c1(nc2c(cc1c1ccccc1)cccc2)SCC(N(C)C)(C)C.Cl
CAS Number
CAS 85275-49-6
PubChem Compound ID
134946
Target and Pathway
Target(s) 5-HT 2 receptor Target Info Modulator [533671]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
References
Ref 544978Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001766)
Ref 5336715-HT2 receptor blockade by ICI 170,809 does not affect the inhibitory effect of the 5-HT1A receptor ligand gepirone on neuroleptic-induced catalepsy. Braz J Med Biol Res. 1994 Oct;27(10):2437-41.

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